Mast cells as biomarkers of inflamm-ageing

Most mechanisms of ageing are believed to be more or less associated with inflammation. With age, a unique form chronic inflammation develops which is termed as inflamm-ageing. The this process still not fully clear due the lack reliable assessment criteria. Immune system among those involved in accelerating age-related changes body. It also directly participates In its pathogenesis, reaction mast cells may great importance. role tissue remodeling deserves special attention, since latter event main features ageing. Hence, inflamm-ageing considered sufficient indicator ageing, and could provide biomarkers process. order test proposed hypothesis, present study was conducted determine morpho-functional cell populations various organs rats. Some parameters (number, synthetic functional activity, degree maturation) different animal were evaluated male Wistar rats ages (4 months 2 years). We have found age-dependent upon examination thymus, adrenal glands, skin, i.e., decrease number their capacity, along significantly increased activity. stomach, small large intestines, at constant cells, we revealed ability, These accompanied by enlargement blood vessels studied organs. Liver only organ did exhibit any age. detected play an important formation events, accompany processes, because these integral component inflammatory response. progression leads accumulation cytokines pro-inflammatory mediators tissues, which, turn, activate cells. At same time, degranulation mastocytes promote oberved mutual influence makes it possible consider potential candidates for searching